Blar i forfatter "Tansirichaiya, Supathep"

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    • Capture of a novel, antibiotic resistance encoding, mobile genetic element from Escherichia coli using a new entrapment vector 

      Tansirichaiya, Supathep; Moyo, Sabrina John; Al-Haroni, Mohammed; Roberts, Adam P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-01)
      <b><p>Aims</b> Antimicrobial resistance genes (ARGs) are often associated with mobile genetic elements (MGEs), which facilitate their movement within and between bacterial populations. Detection of mobility is therefore important to understand the dynamics of MGE dissemination and their associated genes, especially in resistant clinical isolates that often have multiple ARGs associated with MGEs. ...

    • Detection of mobile genetic elements associated with antibiotic resistance in Salmonella enterica using a newly developed web tool: MobileElementFinder 

      Johansson, Markus H; Bortolaia, Valeria; Tansirichaiya, Supathep; Aarestrup, Frank M.; Roberts, Adam P.; Petersen, Thomas Nordahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-03)
      <i>Objectives</i> - Antimicrobial resistance (AMR) in clinically relevant bacteria is a growing threat to public health globally. In these bacteria, antimicrobial resistance genes are often associated with mobile genetic elements (MGEs), which promote their mobility, enabling them to rapidly spread throughout a bacterial community.<p> <i>Methods</i> - The tool MobileElementFinder was developed ...

    • Functional screening of a human saliva metagenomic DNA reveal novel resistance genes against sodium hypochlorite and chlorhexidine 

      Wigand, Johannes; Tansirichaiya, Supathep; Winje, Endre; Al-Haroni, Mohammed (Journal article; Tidsskriftartikkel; Peer reviewed; Mastergradsoppgave; Master thesis, 2021-12-09)
      Objective - Many sections of the health care system are facing a major challenge making infectious disease problematic to treat; antimicrobial resistance (AMR). Identification and surveillance of the resistome have been highlighted as one of the strategies to overcome the problem. This study aimed to screen for AMR genes in an oral microbiota, a complex microbial system continuously exposed to ...

    • Intracellular Transposition and Capture of Mobile Genetic Elements following Intercellular Conjugation of Multidrug Resistance Conjugative Plasmids from Clinical Enterobacteriaceae Isolates 

      Tansirichaiya, Supathep; Goodman, Richard N.; Guo, Xinyu; Bulgasim, Issra; Samuelsen, Ørjan; Al-Haroni, Mohammed; Roberts, Adam P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-19)
      Mobile genetic elements (MGEs) are often associated with antimicrobial resistance genes (ARGs). They are responsible for intracellular transposition between different replicons and intercellular conjugation and are therefore important agents of ARG dissemination. Detection and characterization of functional MGEs, especially in clinical isolates, would increase our understanding of the underlying ...

    • Inverse PCR-based detection reveal novel mobile genetic elements and their associated genes in the human oral metagenome 

      Tansirichaiya, Supathep; Winje, Endre; Wigand, Johannes; Al-Haroni, Mohammed (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-27)
      The human oral cavity is one of the hotspots harboring multiple mobile genetic elements (MGEs), which are segments of DNA that can move either within bacterial genomes or between bacterial cells that can facilitate the spreading of genetic materials, including antimicrobial resistance genes. It is, therefore, important to investigate genes associated with the MGEs as they have a high probability of ...

    • Promoter activity of ORF-less gene cassettes isolated from the oral metagenome 

      Tansirichaiya, Supathep; Mullany, Peter; Roberts, Adam P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-10)
      Integrons are genetic elements consisting of a functional platform for recombination and expression of gene cassettes (GCs). GCs usually carry promoter-less open reading frames (ORFs), encoding proteins with various functions including antibiotic resistance. The transcription of GCs relies mainly on a cassette promoter (P<sub>C</sub>), located upstream of an array of GCs. Some integron GCs, called ...

    • The Transposon Registry 

      Tansirichaiya, Supathep; Rahman, Mohammad Ajijur; Roberts, Adam P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-09)
      Transposable elements in prokaryotes are found in many forms and therefore a robust nomenclature system is needed in order to allow researchers to describe and search for them in publications and databases. Here we provide an update on The Transposon Registry which allocates numbers to any prokaryotic transposable element. Additionally, we present the completion of registry records for all transposons ...